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As it is already known so far, the COVID-19-associated incidence and mortality are explained by pathological changes of an immune response of the patient. Two contradictory hypotheses are made: the defeat mediated by a hyper inflammatory "tsitokinovy storm" and the disturbance of an immunologic protective mechanism of the owner leading to uncontrollable spread of a virus and defeat of bodies. The lack of diagnostic tools for assessment of immune function is the key reason of inability to explain such contradiction at COVID-19 infection.